{"title":"Tolperisone for the treatment of low back pain","authors":"N. Titova","doi":"10.32756/0869-5490-2022-2-14-19","DOIUrl":null,"url":null,"abstract":"Tolperisone is a centrally acting muscle relaxant that shows analgesic activity and can be used alone or in combination with NSAIDs for the treatment of nonspecific back pain. Compared with other muscle relaxants tolperison has better safety profile and very low sedative activity. New extendedrelease form of tolperisone (Midocalm Long 450 mg) has optimized pharmacokinetic properties, which enable stable therapeutic blood concetrantion of active substance over 24 hours. Once-daily administration of prolonged acting drug improves adherence to treatment.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical pharmacology and therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32756/0869-5490-2022-2-14-19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Tolperisone is a centrally acting muscle relaxant that shows analgesic activity and can be used alone or in combination with NSAIDs for the treatment of nonspecific back pain. Compared with other muscle relaxants tolperison has better safety profile and very low sedative activity. New extendedrelease form of tolperisone (Midocalm Long 450 mg) has optimized pharmacokinetic properties, which enable stable therapeutic blood concetrantion of active substance over 24 hours. Once-daily administration of prolonged acting drug improves adherence to treatment.
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