Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq

Banan Kareem Bedewi, Ghaith Ali Jasim, Ibrahim Saleh Abbas, BasmaTalib Al-Sudani
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引用次数: 3

Abstract

oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities. Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq,  and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.
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隐绿原酸对伊拉克辣木叶乳腺癌细胞株MCF7的细胞毒性研究
辣木科油辣木是一种快速生长的乔木。油橄榄干叶具有高酚类化合物的特点。酚类化合物具有抗癌、抗菌、抗炎、抗过敏和抗氧化活性。因此,本研究采用制备薄层色谱法从伊拉克油橄榄叶中分离隐绿原酸,并采用MTT细胞活力测定法研究其对乳腺癌细胞系(MCF7)的细胞毒性作用,并与标准抗癌药物(他莫昔芬)进行比较。分离得到的隐绿原酸对MCF7细胞株具有细胞毒性,IC50为20.8M。
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