Processes for the synthesis of γ-acetopropyl alcohol

V. E. Tarabanko, M. Smirnova, E. Zhizhina
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Abstract

The literature on the existing processes for the synthesis of γ-acetopropyl alcohol (acetopropanol, 5-hydroxypentan-2-one, APA) is reviewed. This substance is used to produce vitamin B1, antimalarial drugs and polymers. The promising methods for APA production are the hydrogenation-hydration of sylvan (2-methylfuran), hydrogenation of furfural, and syntheses based on allyl acetate, sodium acetoacetic ether, and γ-butyrolactone.
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γ-乙酰丙醇的合成工艺
综述了γ-乙酰丙醇(乙酰丙醇,5-羟基戊烷-2- 1,APA)的现有合成工艺。这种物质被用来生产维生素B1、抗疟疾药物和聚合物。目前比较有前途的APA合成方法有:森林(2-甲基呋喃)加氢水化法、糠醛加氢法、醋酸烯丙酯、乙酰乙酸钠和γ-丁内酯合成法。
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