Comorbid laboratory abnormalities in female pattern hair loss patients

IF 2.3 4区 医学 Q2 DERMATOLOGY Dermatologica Sinica Pub Date : 2022-07-01 DOI:10.4103/1027-8117.357357
Hsin-Jou Wang, Jui-Wen Yeh, Yin-Fan Chang, J. Wu, Chao-Chun Yang
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引用次数: 2

Abstract

Background: Female pattern hair loss (FPHL) is the main cause of alopecia in women and has a debilitating impact on the quality of life. However, certain comorbid conditions causing hair loss are often masked by FPHL and may remain undetected. Hence, it is imperative to identify them to administer appropriate treatment. The necessity of laboratory tests to evaluate these comorbidities in patients with FPHL has not been established. Objectives: This study aimed to identify the frequency of comorbid abnormalities detected by laboratory tests in patients with FPHL. Methods: Routine laboratory test results of patients with FPHL, who visit our hair clinic for the first time, were retrospectively collected and analyzed. These tests assessed the serum testosterone, thyroid-stimulating hormone, free thyroxin, zinc and ferritin levels, hemoglobin, as well as antinuclear antibody (ANA), and rapid plasma reagin test results. The correlation between age and hair loss severity and the frequency of comorbidities was evaluated using subgroup analysis. Results: Among the 356 patients with FPHL, coexisting zinc deficiency, iron depletion, and thyroid abnormalities were common and present in 41.7%, 39.7%, and 11.3% of them, respectively. The rate of concomitantly increased ANA titers was relatively low (4.4%), while that of syphilis and high serum testosterone levels was extremely low (0.3% and 0%, respectively). Younger patients (<50 years) with FPHL had a higher rate of coexisting iron deficiency than patients in the older age group. Conclusion: Testing for concomitant iron depletion, zinc deficiency, and thyroid disease is recommended in female patients with FPHL.
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女性型脱发患者的合并症实验室异常
背景:女性型脱发(FPHL)是女性脱发的主要原因,并对生活质量产生不利影响。然而,某些导致脱发的合并症通常被FPHL掩盖,可能仍然未被发现。因此,必须识别它们并给予适当的治疗。实验室检查评估FPHL患者这些合并症的必要性尚未确定。目的:本研究旨在通过实验室检查确定FPHL患者共病异常的频率。方法:回顾性收集首次来发门诊就诊的FPHL患者的常规实验室检查结果并进行分析。这些测试评估了血清睾酮、促甲状腺激素、游离甲状腺素、锌和铁蛋白水平、血红蛋白以及抗核抗体(ANA)和快速血浆反应素测试结果。使用亚组分析评估年龄和脱发严重程度以及合并症发生频率之间的相关性。结果:在356例FPHL患者中,同时存在缺锌、缺铁和甲状腺异常较为常见,分别占41.7%、39.7%和11.3%。伴随ANA滴度升高的比例相对较低(4.4%),而梅毒和高血清睾酮水平的比例极低(分别为0.3%和0%)。年轻的FPHL患者(<50岁)合并缺铁的比例高于老年患者。结论:建议女性FPHL患者同时检测缺铁、缺锌和甲状腺疾病。
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来源期刊
Dermatologica Sinica
Dermatologica Sinica DERMATOLOGY-
CiteScore
2.80
自引率
20.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.
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