Remarkable intra-cerebral lesions on MRI in a patient with Noonan syndrome

Abstract

Noonan syndrome is an autosomal dominant condition with a wide variation in phenotypic expression. We report a case of a young man diagnosed with Noonan syndrome on the grounds of the classical PTPN-11 mutation, whose brain MRI performed for the evaluation of progressive gait-disorders showed remarkable intra-cerebral lesions.