{"title":"Dual Opposed Survival-supporting and Death-promoting Roles of Autophagy in Cancer Cells: A Concise Review","authors":"E. El-Shafey, E. Elsherbiny","doi":"10.2174/2212796813666191111142824","DOIUrl":null,"url":null,"abstract":"\n\nAutophagy is a well-maintained process by which the cells recycle intracellular\nmaterials to maintain homeostasis in various cellular functions. However, autophagy is a defensive\nmechanism that maintains cell survival under antagonistic conditions, the induction\nof the autophagic process may substantially lead to cell death. The conflicting roles of autophagy\nincluding allowing cell survival or promoting cell death could have a troublesome impact\non the efficiency of chemotherapeutic agents. Accordingly, understanding the role of\nautophagy in cancer is a vital need for its optimal manipulation in therapy.\n","PeriodicalId":10784,"journal":{"name":"Current Chemical Biology","volume":"85 1","pages":"4-13"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Chemical Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2212796813666191111142824","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Autophagy is a well-maintained process by which the cells recycle intracellular
materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive
mechanism that maintains cell survival under antagonistic conditions, the induction
of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy
including allowing cell survival or promoting cell death could have a troublesome impact
on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of
autophagy in cancer is a vital need for its optimal manipulation in therapy.
期刊介绍：
Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems. Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).
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