EPIDEMIOLOGICAL STUDY OF MAIN CLONES DISTRIBUTION GENOTYPE BEIJING OF MYCOBACTERIUM TUBERCULOSIS WITHIN IRKUTSK REGION

Q3 Medicine Zhurnal mikrobiologii, epidemiologii, i immunobiologii Pub Date : 2017-12-28 DOI:10.36233/0372-9311-2017-6-88-94

Н. Жданова, ' О.Б.Огарков, В. Синьков, ПЛ. Хромова, Е. А. Орлова, М. Е. Кощеев, Е. Д. Савилов, N. Zhdanova, O. Ogarkov, V. Sinkov, P. Khromova, E. Orlova, M. Koscheev, E. Savilov

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引用次数: 7

Abstract

To the pathogen in the Irkutsk region by comparison of genotypes of M. tuberculosis from patients of different age groups. Materials and methods. 588 epidemiologically unrelated strains of M. tuber culosis isolates from 567 ТВ patients were characterized using 24-locus MIRU-VNTR typing. 160 strains belonged to patients of different age groups. 59 strains were isolated from the «young» people with ТВ who were bom after 1990 and 101 isolates from people who were bom before 1955. Results. Two-thirds of the samples (427/567) were genotype Beijing with the dominance of two subtypes belonging to the modem epidemic clonal complexes CC1 and CC2. The high level of clustering profiles of СС 1 and CC2 genotype Beijing in «older» and «young» patients in the Irkutsk region indicates the presence and active transmission of epidemic CC1 and CC2 subtypes over the past fifty years.

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伊尔库茨克地区结核分枝杆菌北京基因型主要克隆分布的流行病学研究

对伊尔库茨克地区不同年龄组患者结核分枝杆菌的基因型进行比较。材料和方法。采用24位点MIRU-VNTR分型对567例ТВ患者分离的588株无流行病学相关性的结核分枝杆菌进行了鉴定。160株属于不同年龄组的患者。从1990年以后出生的患有ТВ的“年轻人”中分离出59株菌株，从1955年以前出生的人中分离出101株菌株。结果。其中2 / 3(427/567)为北京型，以现代流行克隆复合物CC1和CC2亚型为主。伊尔库茨克地区“老年”和“年轻”患者中СС 1和CC2基因型北京的高水平聚类特征表明，过去50年来流行CC1和CC2亚型的存在和活跃传播。

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