Natural vaginal progesterone is associated with minimal psychological side effects: a preliminary study.

S. Shantha, J. Brooks-Gunn, R. J. Locke, M. Warren
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引用次数: 11

Abstract

The objective of this study was to evaluate the psychological side effects of a transvaginal natural progesterone gel in hormone replacement therapy (HRT). This 3-month preliminary study was part of a multicenter study previously performed in our center. We enrolled 49 women (ages 18-45 years) with hypothalamic amenorrhea (HA) (n = 40) and premature ovarian failure (POF) (n = 9). Estrogenized patients applied vaginal progesterone gel (4% or 8%) every other day for six doses per month. The Hopkins Symptom Checklist (HSCL), a psychometric profile test, was administered at baseline, day 13 of cycle 2, day 24 of cycle 2, and day 24 of cycle 3. Application of the progesterone gel caused no significant change in HSCL total scores or individual symptom scores for somatization, obsession-compulsion, interpersonal sensitivity, depression, and anxiety. Natural vaginal progesterone gel can be an effective alternative to oral progesterone for women on HRT.
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天然阴道孕酮与最小的心理副作用相关:初步研究。
本研究的目的是评估经阴道天然孕酮凝胶在激素替代疗法(HRT)中的心理副作用。这项为期3个月的初步研究是本中心之前进行的一项多中心研究的一部分。我们招募了49名患有下丘脑闭经(HA) (n = 40)和卵巢早衰(POF) (n = 9)的女性(年龄18-45岁)。接受雌激素治疗的患者每隔一天使用阴道黄体酮凝胶(4%或8%),每月6次。在基线、第2周期第13天、第2周期第24天和第3周期第24天进行霍普金斯症状检查表(HSCL),这是一种心理测量量表。应用黄体酮凝胶后,HSCL总分和躯体化、强迫、人际敏感、抑郁、焦虑等单项症状评分均无显著变化。天然阴道孕酮凝胶可以有效替代口服孕酮的妇女在HRT。
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