{"title":"Remedy Efficiency through Paclitaxel on Rat (Rattus norvegicus) Brain Injury and\n Risk Premium of N- Diethyl nitrosamine (DEN) Injection","authors":"Bashdar Saeed, Hamad amin, B. Hamdi","doi":"10.30526/36.2.3026","DOIUrl":null,"url":null,"abstract":"Abstract The current study deals with the effect of N-Diethylnitrosamine (DEN)\n induced traumatic brain injury on male albino rats, as well as the outcome results of\n treatment with paclitaxel nanoparticles for a period of 8 weeks with two-week intervals\n is the concern of the present study. Mean body weight, as well as brain weight, was\n considered as the main parameters whereas a detailed immunohistochemical study on rat\n brain sections was performed. Astrocytic biomarkers for the diagnosis of astrocytes by\n fibrillary glial acidic protein (GFAP). Neuronal GFAP staining used for various broke\n sections were forwarded. Comparison and Contrast of all these parameters in all steps of\n the experiment had been discussed. The efficiency of the treatment was found to be\n evident. The effect on body weight was significant whereas brain weight results showed\n insignificant differences. A longer duration of treatment may well reflect more\n significant results.","PeriodicalId":13022,"journal":{"name":"Ibn AL- Haitham Journal For Pure and Applied Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ibn AL- Haitham Journal For Pure and Applied Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30526/36.2.3026","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract The current study deals with the effect of N-Diethylnitrosamine (DEN)
induced traumatic brain injury on male albino rats, as well as the outcome results of
treatment with paclitaxel nanoparticles for a period of 8 weeks with two-week intervals
is the concern of the present study. Mean body weight, as well as brain weight, was
considered as the main parameters whereas a detailed immunohistochemical study on rat
brain sections was performed. Astrocytic biomarkers for the diagnosis of astrocytes by
fibrillary glial acidic protein (GFAP). Neuronal GFAP staining used for various broke
sections were forwarded. Comparison and Contrast of all these parameters in all steps of
the experiment had been discussed. The efficiency of the treatment was found to be
evident. The effect on body weight was significant whereas brain weight results showed
insignificant differences. A longer duration of treatment may well reflect more
significant results.
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