The effect of Moringa oleifera leaf powder on hydroxychloroquine -induced kidney tissues injury

Abstract

The present study was conducted to investigate the possible protective effect of Moringa oleifera leaves powder on Hydroxychloroquine induced kidney tissue injury. White male rats were used, and dried Moringa leaf powder was given to them with lunch for 3 weeks to play a protective role in the body, they were dosed orally  by tube prepared daily for 5 days with hydroxychloroquine in different doses (1000, 500,250 mg /kg b.wt). Urea and creatinine levels were determined in the serum in addition to the histopathology of the kidney, and the hematological effects were determined for this medicine in the rats. The results showed a significant increase in the urea level and the concentration of creatinine in rats that had been given hydroxychloroquine compared to normal and treated groups with M. oleifera. Also, treatment with M. oleifera  showed a very significant drop in urea level. There was  an apparent change in the urea level with experience. A significant increase in the count of RBCs was recorded for the hydroxychloroquine group concentration of 1000 mg/kg, compared to the control group and the other groups. And that recorded significant increase in the content of Hb and count of Platelet was recorded for the hydroxychloroquine group concentration 1000 mg/kg, compared to the control group and the other group's .at P value < 0.05. The effects of tissue degradation by hydroxychloroquine were improved when treated with Moringa oleifera  leaves  powder.