The Effects of Baicalin and Geniposide in Combination on Microglial Activation and 5-Lipoxygenase Expression in Rats during Recovery from Cerebral Ischemia
Yang Wang, Han Liu, Jie Wu, Lu Zhao, Hanghang Zhang, Qianqian Sun, Andong Zhao, Hongfang Zhang, Bin Wang
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Abstract
Background and objectives: This study aimed to analyze the effects of baicalin (BC) and geniposide (GP) in combination (7:3) on the activation of microglia (MG) and 5-lipoxygenase (5-LOX) expression in rats during the recovery period after cerebral ischemia and to determine whether inhibition of the 5-LOX pathway is beneficial for M1-to-M2 polarization of MG. Methods: Sprague Dawley rats were divided into five groups: control, model
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