Radiolabeled 75Se-silica nanoparticles: synthesis, characterization and coating with ω-functionalized alkylsilane compounds

S Brandriss , G Borchardt , J Kreuter , S Margel
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引用次数: 3

Abstract

The synthesis and characterization of new radiolabeled 75Se-silica nanoparticles are described. These particles have been prepared by dispersion polymerization of tetraethylorthosilicate in ethanol in presence of radiolabeled 75selenium-colloids. The amount of Se-colloids encapsulated within the silica matrix was then increased by two successive seeded polymerizations of tetraethylorthosilicate on the previously formed particles. Kinetic studies and the effect of various factors, i.e. sodium selenite, water and ammonium hydroxide concentrations, on the diameter of these nanoparticles have been elucidated. The Se-silica nanoparticles have been covalently coated by the self-assembled technique with a variety of ω-functionalized alkylsilane compounds. Characterization of these coatings has been performed by Fourier transform-infrared spectroscopy, elemental analysis and floatability studies. The potential use of these varieties of ω-functionalized radiolabeled nanoparticles for drug delivery purposes has been demonstrated in a separate article.

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放射性标记的75se -二氧化硅纳米粒子:ω功能化烷基硅烷化合物的合成、表征和涂层
介绍了新型放射性标记的75se -二氧化硅纳米粒子的合成和表征。这些颗粒是在放射性标记的75硒胶体存在下,用四乙基硅酸盐在乙醇中分散聚合制备的。然后通过在先前形成的颗粒上连续两次四乙基硅酸的种子聚合,增加了硅基体内包裹的硒胶体的数量。研究了亚硒酸钠、水浓度和氢氧化铵浓度等因素对纳米颗粒直径的影响。采用自组装技术将多种ω功能化烷基硅烷化合物包覆在se -二氧化硅纳米颗粒上。通过傅里叶变换红外光谱、元素分析和可浮性研究对这些涂层进行了表征。这些ω功能化放射性标记纳米颗粒用于药物递送目的的潜在用途已在另一篇文章中得到证实。
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