Neoantigen: A New Hope for Effective Cancer Immunotherapy

N. Khansari
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Abstract

In recent years, immunotherapy with the aim of augmenting the body's immune system to recognize and destroy tumor cell has been widely investigated as a novel cancer therapy modality. Immune responses can be naturally generated against cancer cells. On the other hand, cancer cells can inhibit anticancer immune responses. In the past decades, vaccination with tumor specific/associated antigens and immunogenic vectors has been successfully used to increase antitumor immune responses. However, the choice of target antigen is imperative in designing a cancer vaccine.
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新抗原:癌症有效免疫治疗的新希望
近年来,以增强机体免疫系统识别和破坏肿瘤细胞为目的的免疫治疗作为一种新的癌症治疗方式得到了广泛的研究。免疫反应可以自然产生对抗癌细胞。另一方面,癌细胞可以抑制抗癌免疫反应。在过去的几十年里,用肿瘤特异性/相关抗原和免疫原性载体接种疫苗已成功地用于增强抗肿瘤免疫反应。然而,在设计癌症疫苗时,靶抗原的选择是必不可少的。
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