Synthesis and characterization of mononuclear copper(II) complex of tetradentate N2S2 donor set and the study of DNA and bovine serum albumin binding

Abstract

One mononuclear copper(II) complex, containing neutral tetradentate NSSN-type ligands, of formulation [Cu II(L 1)Cl]ClO 4 (1), was synthesized and isolated in pure form [where L 1˭ 1,3-bis(3-pyridylmethylthio)propane]. Green-colored copper(II) complex was characterized by physicochemical, spectroscopic methods and conductivity measurement. These experimental data matched well with the proposed structure of the complex. Biological activity of the complex (1) toward calf thymus DNA and bovine serum albumin has been examined systematically and groove-binding behavior of the Copper(II) complex 1 with calf thymus DNA has been observed from the spectral study.