Perspectives on the Multidisciplinary role of Bioanalysis: an Interview with Prof. Marcello Locatelli

Abstract

Before considering the different questions related to this interview, we need to know about the definition of “Bioanalysis”: “Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative determination of xenobiotics (e.g. drugs, metabolites, and biological molecules in atypical locations or concentrations) and biotics (e.g. macromolecules, proteins, DNA, large molecule drugs, metabolites, biopharmaceuticals) in biological systems. Its main focus in the pharmaceutical field is to provide quantitative information about the active drug and/or its metabolite(s) for pharmacokinetics, toxicokinetics, bioequivalence, exposure-response, and adsorption/distribution/ metabolism/excretion (ADME). Bioanalysis also applies to drugs used for non-specific purposes, forensic investigations, anti-doping testing, and environmental concerns”. University “G. d’ Annunzio” of Chieti-Pescara, Department of Pharmacy, Chieti, Italy.