Utilisation of MMW Radiation to Facilitate Apoptosis in Triple Negative Breast Cancer Cell Lines via TRPV1 Receptor Sensitization

Abstract

Triple-negative breast cancers (TNBC) are highly aggressive malignancies comprising ~15-20 % of all breast cancers. TNBCs quickly acquire drug resistance mechanisms and are inherently resistant to radiotherapy, which significantly limits therapeutic options. Thus, there is a need to develop more selective and efficient therapeutic approaches to target this cancer subtype. In this study we investigate the applicability of MMW radiation as co-factor for prolonged sensitisation of TRPV1 receptor to promote the maximal channel activation with minimal tachyphylaxis to increase cancer cell death in TNBC.