Antihypertensive and Vasorelaxant Effects of Rumex vesicarius (L.) through Receptor-Operated Calcium Channels in Hypertensive Rats.

IF 5.3 2区物理与天体物理 Q1 ASTRONOMY & ASTROPHYSICS Physical Review D Pub Date : 2022-01-01 DOI:10.2174/1871529X22666220531110308

Ayoub Amssayef, Ismail Bouadid, Ahmed El-Haidani, Mohamed Eddouks

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Abstract

Aims: The aim of the study was to assess the antihypertensive activity of Rumex vesicarius.

Background: The genus Rumex (sorrel, Polygonaceae), containing approximately 200 species, is distributed worldwide (African, European, Asian, and American countries). It is widely used in traditional medicine as analgesic, diuretic, antispasmodic, and antihypertensive plant.

Objectives: This study aimed to assess the possible antihypertensive vasorelaxant capacity and effect on angiotensin-converting enzyme 2 (ACE-2) of the aqueous extract of Rumex vesicarius (R. vesicarius).

Methods: In the present study, the aqueous extract of R. vesicarius (AERV) was prepared, its antihypertensive activity was examined in N(ω)-nitro-L-arginine methyl ester(L-NAME)-induced hypertensive rats, and its vasorelaxant ability along with its effect on stimulating or inhibiting ACE-2 were determined in isolated rat thoracic aorta.

Results: The results indicated that AERV decreased the systolic, diastolic, mean, and mean arterial blood pressure in hypertensive rats. The data revealed that AERV exerted its antihypertensive effect through vasodilatory properties via an endothelium-independent pathway. Interestingly, the study demonstrated that the vasorelaxation ability of AERV might be mediated through receptor-operated calcium channels (ROCC). However, AERV extract had no effect on either stimulating or inhibiting ACE-2.

Conclusion: The present study demonstrates clearly the antihypertensive and vasorelaxant activities of R. vesicarius in hypertensive rats, supporting its beneficial action as an antihypertensive agent.

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通过受体操作的钙通道对高血压大鼠产生抗高血压和舒张血管的作用。

研究目的：本研究旨在评估鲁米克斯（Rumex vesicarius）的抗高血压活性：背景：苏木属（蓼科）包含约 200 个物种，分布于世界各地（非洲、欧洲、亚洲和美洲国家）。它在传统医学中被广泛用作镇痛、利尿、解痉和降压植物：本研究旨在评估鲁米克斯（Rumex vesicarius）水提取物可能的抗高血压血管舒张能力和对血管紧张素转换酶 2（ACE-2）的影响：本研究制备了茜草水提取物（AERV），在N(ω)-硝基-L-精氨酸甲酯（L-NAME）诱导的高血压大鼠中检测其抗高血压活性，并在离体大鼠胸主动脉中检测其血管舒张能力及其对ACE-2的刺激或抑制作用：结果表明，AERV 可降低高血压大鼠的收缩压、舒张压、平均血压和平均动脉血压。结果表明，AERV 可降低高血压大鼠的收缩压、舒张压、平均血压和平均动脉压。有趣的是，研究表明 AERV 的血管舒张能力可能是通过受体钙通道（ROCC）介导的。然而，AERV 提取物对刺激或抑制 ACE-2 均无作用：本研究清楚地证明了 R. vesicarius 对高血压大鼠的降压和舒张血管活性，支持其作为降压药的有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physical Review D ASTRONOMY & ASTROPHYSICSPHYSICS, PARTICLES-PHYSICS, PARTICLES & FIELDS

CiteScore

9.30

自引率

36.00%

发文量

3456

期刊介绍： Physical Review D (PRD) is a leading journal in elementary particle physics, field theory, gravitation, and cosmology and is one of the top-cited journals in high-energy physics. PRD covers experimental and theoretical results in all aspects of particle physics, field theory, gravitation and cosmology, including: Particle physics experiments, Electroweak interactions, Strong interactions, Lattice field theories, lattice QCD, Beyond the standard model physics, Phenomenological aspects of field theory, general methods, Gravity, cosmology, cosmic rays, Astrophysics and astroparticle physics, General relativity, Formal aspects of field theory, field theory in curved space, String theory, quantum gravity, gauge/gravity duality.