Quantitative measurement of metal chelation by fourier transform infrared spectroscopy

Monika E. Miller, Lani P. McKinnon, Edward B. Walker
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引用次数: 9

Abstract

Nutritionally important minerals are more readily absorbed by living systems when complexed with organic acids, resulting in higher consumer demand and premium prices for these products. These chelated metals are produced by reaction of metal oxides and acids in aqueous solution. However, unreacted dry blends are sometimes misrepresented as metal chelates, when in reality they are only simple mixtures of the reactants typically used to synthesize them. This practice has increased interest in developing analytical methods that are capable of measuring the extent of metal chelation for quality control and regulatory compliance. We describe a novel method to rapidly measure the percent chelation of citric and malic acids with calcium, magnesium, and zinc. Utilization of attenuated total reflectance (FTIR-ATR) provides for the direct, rapid measurement of solid samples. The inclusion of an internal standard allows independent determination of either free or chelated acids from integrated areas in a single spectrum.

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傅里叶变换红外光谱法定量测定金属螯合作用
当与有机酸复合时,具有重要营养价值的矿物质更容易被生命系统吸收,从而导致消费者对这些产品的更高需求和更高价格。这些螯合金属是由金属氧化物和酸在水溶液中反应产生的。然而,未反应的干混合物有时被误表示为金属螯合物,而实际上它们只是通常用于合成它们的反应物的简单混合物。这种做法增加了开发分析方法的兴趣,这些方法能够测量金属螯合的程度,以进行质量控制和法规遵从性。我们描述了一种快速测量柠檬酸和苹果酸与钙、镁和锌螯合百分比的新方法。利用衰减全反射(FTIR-ATR)提供了固体样品的直接,快速测量。包括一个内部标准允许独立测定自由或螯合酸从集成区域在单一光谱。
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