Effect of Coeliac Disease on Gastrointestinal Tract and Immunity

Abstract

Coeliac disease (CD) is an inflammatory genetic auto immune disease in which the patient have sensitivity against gluten which a protein present in wheat and some food. Once gluten enter the body, this induce immune system to make innate and acquired immune response in which the immune system produce autoantibodies which migrate in to small intestine and induced inflammation which effect on the function of small intestine not only but also the body secreted some mediators which increase the permeability of tissue to these antibodies and maybe cause damage in other organs. No medication for CD, the only treatment method is diet which gluten free in addition to the patients must be take some supplementation as a result of deficiency consequence since mal absorption. If this disease not diagnosis early it may be developed to produce different type of malignancy.