Jelena Janković, Branislav Ilić, Nataša Đurđević, Aleksandar Jandrić
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引用次数: 0
Abstract
Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need multidisciplinary approach and efficient biomarkers. Acid-fast bacilli (AFB) staining, cultures and pathophysiological biopsy finding from the majority of patients are positive only in less than 10%. Löwenstein culture results need time about 6-8 weeks what delays diagnosis. Adenosine deaminase (ADA) is biomarker with high sensitivity and specificity (more than 90%) and considered as gold standard of biomarkers in the diagnosis of TP. It is very hard to distinguish malignant from TP with lymphocyte predomination, but in patient with malignant pleural effusion the level of ADA is decreased, opposite from TP. ADA in pleural punctate is a fast, simple, efficient and economical way for clarification the etiology of the pleural effusion as tuberculous pleurisy. Also, many studies have proved the role of ADA in the response to treatment for tuberculosis at follow up period.
结核性胸膜炎(TP)是最常见的肺外结核病之一。由于结核性胸膜炎病程缓慢,症状和诊断方法缺乏特异性,因此很难诊断。因此,我们需要多学科方法和有效的生物标志物。大多数患者的酸性ast杆菌(AFB)染色、培养和病理生理学活检结果只有不到10%呈阳性。洛文氏菌培养结果需要 6-8 周的时间,这延误了诊断。腺苷脱氨酶(ADA)是一种灵敏度和特异性都很高(超过 90%)的生物标记物,被认为是诊断 TP 的金标准生物标记物。通过淋巴细胞预示很难区分恶性胸腔积液和 TP,但恶性胸腔积液患者的 ADA 水平会下降,这与 TP 相反。胸膜穿刺液中的 ADA 是一种快速、简单、有效且经济的方法,可用于明确胸腔积液是否为结核性胸膜炎。此外,许多研究也证明了 ADA 在随访期间对结核病治疗反应的作用。
期刊介绍:
The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
The Journal publishes original scientific and specialized articles on all aspects of
clinical and medical biochemistry,
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clinical hematology and coagulation,
clinical immunology and autoimmunity,
clinical microbiology,
virology,
clinical genomics and molecular biology,
genetic epidemiology,
drug measurement,
evaluation of diagnostic markers,
new reagents and laboratory equipment,
reference materials and methods,
reference values,
laboratory organization,
automation,
quality control,
clinical metrology,
all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.