Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins

Qiu-Chen Chen, Han Liu, Xuechen Li
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引用次数: 1

Abstract

It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell surface. It presents as a terminal structure on either glycoproteins or glycolipids and has been demonstrated to be related to various biological processes, such as fertilization and selectin binding. Due to the vital role of sLeX, its synthesis as well as its determination approaches have attracted considerable attention from many researchers. In this review, the focus is sLeX on glycoproteins. The biological importance of sLeX in fertilization and development, immunity, cancers, and other aspects will be first introduced. Then the chemical and enzymatic synthesis of sLeX including the contributions from more than 15 international research groups will be described, followed by a brief view of the sLeX detection focusing on monosaccharides and linkages. This review is valuable for those readers who are interested in the chemistry and biology of sLeX.
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唾液酸Lewis X对糖蛋白的基本功能、合成及检测
普遍认为,sialyl Lewis X (sLeX)通常附着在细胞表面,其组成和链接为n -乙酰神经氨酸(Neu5Ac) α2-3 -半乳糖(Gal) β1-4 [focal (Fuc) α1-3] n -乙酰氨基葡萄糖。它是糖蛋白或糖脂的末端结构,已被证明与多种生物过程有关,如受精和选择素结合。由于sLeX的重要作用,它的合成及其测定方法引起了许多研究者的广泛关注。本文就糖蛋白的sLeX进行综述。首先介绍sLeX在受精发育、免疫、癌症等方面的生物学意义。然后介绍了sLeX的化学和酶合成,包括超过15个国际研究小组的贡献,然后简要介绍了sLeX的检测,重点是单糖和键。这篇综述对那些对sLeX的化学和生物学感兴趣的读者很有价值。
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