ESR: Optimizing Gene Feature Selection for scRNA-seq Data

Abstract

The rapid development of single-cell RNA sequencing (scRNA-seq) technology has enabled researchers to explore gene expression differences at the level of individual cells, revealing more refined cell types and states. However, due to the low expression and high noise of scRNA-seq data, feature selection has become particularly important in the analysis of single-cell data. Here, we introduce the Entropy Stepwise Regression (ESR) method for feature selection. This method utilizes the correlation between genes and the entropy values of each feature to filter out genes that are conducive to downstream analysis. In mouse kidney samples, we compared the performance of three methods in terms of Adjusted Rand Index and achieved good results. This indicates that the method can improve the accuracy of downstream analysis.