The Correlation of Fc-gamma Receptor I (CD64) Expression and Procalcitonin in Early Onset Neonatal Sepsis

Abstract

Objective: The aim of this study is to prove the relationship of FcγRI (CD64) expression and Procalcitonin value in earlyonset neonatal sepsis to assist in diagnosis of early-onset neonatal sepsis. Method: A descriptive and analytical case control study was conducted in dr. Saiful Anwar General Hospital Malang. There were 40 children divided into two groups: 1). Group of infants with neonatal risk factors who express signs of SIRS and proven by blood culture; 2). Group of infants with neonatal risk factors who showed no sign for SIRS. Both groups were performed examination of FcγRI (CD64) expression with flowcytometry and Procalcitonin value with ELISA. Data were statistically analyzed using normality test (Kolmogorov-Smirnov), chi square test, t test and Pearson correlation. We used SPSS 16 for this analysis. Results: The study showed that the FcγRI (CD64) expression and Procalcitonin value were higher in the infants group with proven early-onset neonatal sepsis (p less than 0.05). There was a significant relationship between FcγRI (CD64) expression and the Procalcitonin value (p=0.036). Conclusions: We conclude that expression of FcγRI (CD64) and Procalcitonin value were higher in the infants group with proven early-onset neonatal sepsis. There is a positive relationship between FcγRI (CD64) expression and Procalcitonin value in early onset neonatal sepsis