CHAPTER 7. Novel Functions of Vitamin E Nicotinate

Y. Suzuki, L. Marcocci, K. R. Duncan, D. I. Suzuki, N. Shults
{"title":"CHAPTER 7. Novel Functions of Vitamin E Nicotinate","authors":"Y. Suzuki, L. Marcocci, K. R. Duncan, D. I. Suzuki, N. Shults","doi":"10.1039/9781788016216-00088","DOIUrl":null,"url":null,"abstract":"Vitamin E nicotinate is an ester of tocopherol (vitamin E) and niacin (vitamin B3). While this ester can be chemically synthesized, whether vitamin E nicotinate is formed from vitamin E and niacin in the biological system is unclear. Our previous metabolomics analysis demonstrated that the heart tissue level of vitamin E nicotinate is 30-fold lower in heart failure. Since the rat diet used in these experiments contained vitamin E acetate and niacin separately, but not in the form of vitamin E nicotinate, these results revealed that vitamin E and niacin could be esterified to form vitamin E nicotinate in the biological system. Observations that the vitamin E nicotinate level gets altered in the disease state suggest clinical importance. While it was expected that oxidative stress occurring during heart failure decreases the levels of various antioxidants, only vitamin E nicotinate, but not other forms of vitamin E including α-tocopherol, was reduced. Hence, vitamin E nicotinate may function independently from simply serving as a source of active vitamin E. Consistent with this idea, we recently found that the intact vitamin E nicotinate structure could elicit cell signaling for the formation of anandamide. Exciting novel functions of vitamin E nicotinate are discussed.","PeriodicalId":23674,"journal":{"name":"Vitamin E","volume":"48 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vitamin E","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/9781788016216-00088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Vitamin E nicotinate is an ester of tocopherol (vitamin E) and niacin (vitamin B3). While this ester can be chemically synthesized, whether vitamin E nicotinate is formed from vitamin E and niacin in the biological system is unclear. Our previous metabolomics analysis demonstrated that the heart tissue level of vitamin E nicotinate is 30-fold lower in heart failure. Since the rat diet used in these experiments contained vitamin E acetate and niacin separately, but not in the form of vitamin E nicotinate, these results revealed that vitamin E and niacin could be esterified to form vitamin E nicotinate in the biological system. Observations that the vitamin E nicotinate level gets altered in the disease state suggest clinical importance. While it was expected that oxidative stress occurring during heart failure decreases the levels of various antioxidants, only vitamin E nicotinate, but not other forms of vitamin E including α-tocopherol, was reduced. Hence, vitamin E nicotinate may function independently from simply serving as a source of active vitamin E. Consistent with this idea, we recently found that the intact vitamin E nicotinate structure could elicit cell signaling for the formation of anandamide. Exciting novel functions of vitamin E nicotinate are discussed.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
第七章。维生素E烟酸盐的新功能
维生素E烟酸盐是一种生育酚(维生素E)和烟酸(维生素B3)的酯。虽然这种酯可以化学合成,但维生素E烟酸盐是否由生物系统中的维生素E和烟酸形成尚不清楚。我们之前的代谢组学分析表明,心脏组织中维生素E烟酸盐的水平在心力衰竭中低30倍。由于实验中使用的大鼠饲料中分别含有维生素E醋酸酯和烟酸,但不以维生素E烟酸盐的形式存在,因此这些结果表明,维生素E和烟酸盐可以在生物系统中酯化形成维生素E烟酸盐。观察到维生素E烟酸水平在疾病状态下发生改变,这表明临床重要性。虽然预计心力衰竭期间发生的氧化应激会降低各种抗氧化剂的水平,但只有维生素E烟酸盐会降低,而包括α-生育酚在内的其他形式的维生素E则不会降低。因此,维生素E烟酸盐可以独立发挥作用,而不仅仅是作为活性维生素E的来源。与这一观点一致,我们最近发现,完整的维生素E烟酸盐结构可以引发细胞信号传导,形成anandamide。本文讨论了维生素E烟酸盐令人兴奋的新功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
CHAPTER 11. Vitamin E Inspired Synthetic Antioxidants CHAPTER 9. Lipid Peroxidation: Role of Vitamin E CHAPTER 12. Action of Vitamin E Against Lipid Peroxidation and Cell Death CHAPTER 14. Metabolism of Vitamin E CHAPTER 13. Oxidation Products of Vitamin E with Lipid-derived Free Radicals
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1