Y. Suzuki, L. Marcocci, K. R. Duncan, D. I. Suzuki, N. Shults
{"title":"CHAPTER 7. Novel Functions of Vitamin E Nicotinate","authors":"Y. Suzuki, L. Marcocci, K. R. Duncan, D. I. Suzuki, N. Shults","doi":"10.1039/9781788016216-00088","DOIUrl":null,"url":null,"abstract":"Vitamin E nicotinate is an ester of tocopherol (vitamin E) and niacin (vitamin B3). While this ester can be chemically synthesized, whether vitamin E nicotinate is formed from vitamin E and niacin in the biological system is unclear. Our previous metabolomics analysis demonstrated that the heart tissue level of vitamin E nicotinate is 30-fold lower in heart failure. Since the rat diet used in these experiments contained vitamin E acetate and niacin separately, but not in the form of vitamin E nicotinate, these results revealed that vitamin E and niacin could be esterified to form vitamin E nicotinate in the biological system. Observations that the vitamin E nicotinate level gets altered in the disease state suggest clinical importance. While it was expected that oxidative stress occurring during heart failure decreases the levels of various antioxidants, only vitamin E nicotinate, but not other forms of vitamin E including α-tocopherol, was reduced. Hence, vitamin E nicotinate may function independently from simply serving as a source of active vitamin E. Consistent with this idea, we recently found that the intact vitamin E nicotinate structure could elicit cell signaling for the formation of anandamide. Exciting novel functions of vitamin E nicotinate are discussed.","PeriodicalId":23674,"journal":{"name":"Vitamin E","volume":"48 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vitamin E","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/9781788016216-00088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Vitamin E nicotinate is an ester of tocopherol (vitamin E) and niacin (vitamin B3). While this ester can be chemically synthesized, whether vitamin E nicotinate is formed from vitamin E and niacin in the biological system is unclear. Our previous metabolomics analysis demonstrated that the heart tissue level of vitamin E nicotinate is 30-fold lower in heart failure. Since the rat diet used in these experiments contained vitamin E acetate and niacin separately, but not in the form of vitamin E nicotinate, these results revealed that vitamin E and niacin could be esterified to form vitamin E nicotinate in the biological system. Observations that the vitamin E nicotinate level gets altered in the disease state suggest clinical importance. While it was expected that oxidative stress occurring during heart failure decreases the levels of various antioxidants, only vitamin E nicotinate, but not other forms of vitamin E including α-tocopherol, was reduced. Hence, vitamin E nicotinate may function independently from simply serving as a source of active vitamin E. Consistent with this idea, we recently found that the intact vitamin E nicotinate structure could elicit cell signaling for the formation of anandamide. Exciting novel functions of vitamin E nicotinate are discussed.