Metadichol® a Novel Agonist of the Anti-aging Klotho Gene in Cancer Cell Lines

Abstract

The Greek goddess whose name is associated with Klotho protein spins life’s thread and is associated with reversing aging in mammals. In Greek Mythology, Klotho has two siblings, Lachesis and Atropos, and one determines the length of the thread of life and the other cuts the thread. Klotho (KL), which was named after one of the three goddesses of fate who controlled aging in Greek mythology, was initially identified in 1997 as the gene responsible for early aging-like symptoms in mice [1], and in several other tissues [2]. It acts as a coreceptor with fibroblast growth factor receptor-1 (FGFR1)to bind fibroblast growth factor 23 (FGF23) and mediate phosphaturia to correct the hyperphosphatemia arising from 1,25-dihydroxy vitamin D (calcitriol or 1,25D) Stimulation of intestinal calcium and phosphate absorption.1,25D regulates the expression of both membrane and soluble klotho forms in multiple kidney cell types to support FGF23 phosphaturic and vitamin D counter-regulatory actions at the kidney, possibly exerting antiaging effects [3].