Mesenchymal Stem Cells Lysate as a Cell-Free Therapy

S. Malik, Tehreem Malik
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引用次数: 2

Abstract

Mesenchymal stem cells (MSCs), a self-renewing and multipotent population of cells, have proved to be a potential regenerative medical therapy option. Initially, it was assumed that the primary mechanism behind MSCs action was cell substitution by differentiation and engraftment at the injury site. However, recent trials have demonstrated that implanted cells do not last long and that the benefits of MSCs therapy may be triggered by a wide number of bioactive factors that are essential for regulating main biological processes. Thus, supporting the paracrine mechanism of action of MSCs. Application of secretome could eliminate the potential risk factors associated with MSCs transplantation, like the unknown fate of cells after transplantation, malignant transformation, and undesired differentiation of MSCs. However, the use of a secretome might not give long-lasting and desired results. Thus, it may intuitively suggest the need for other treatment options. The cellular lysate is considered as an alternate cell-free treatment strategy for the cure of multiple disorders. The present review describes the MSCs secretome/extracellular vesicles and MSCs lysate, derived from bone marrow and adipose, as a cell-free therapy with the application of MSCs lysate for various diseases during the period 2010 to 2020. Moreover, it also highlights the advantages and limitations of each cell-free therapy.
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间充质干细胞裂解液作为一种无细胞疗法
间充质干细胞(MSCs)是一种自我更新和多能的细胞群,已被证明是一种潜在的再生医学治疗选择。最初,人们认为MSCs作用背后的主要机制是通过分化和在损伤部位植入的细胞替代。然而,最近的试验表明,植入的细胞不能持续很长时间,并且MSCs治疗的益处可能是由许多生物活性因子触发的,这些生物活性因子对调节主要的生物过程至关重要。因此,支持MSCs的旁分泌作用机制。应用分泌组可以消除与MSCs移植相关的潜在危险因素,如移植后细胞的未知命运、恶性转化、MSCs的不期望分化等。然而,分泌组的使用可能不会产生持久和理想的结果。因此,它可能直观地提示需要其他治疗方案。细胞裂解液被认为是治疗多种疾病的一种替代的无细胞治疗策略。本文综述了从骨髓和脂肪中提取的MSCs分泌组/细胞外囊泡和MSCs裂解液作为一种无细胞疗法,在2010年至2020年期间应用于各种疾病。此外,它还突出了每种无细胞疗法的优点和局限性。
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