S. Martínez-Bellver, A. Cervera-Ferri, Aina Luque‐García, J. Martínez-Ricós, A. Valverde-Navarro, M. Bataller, Juan Guerrero, V. Teruel-Martí
{"title":"Causal relationships between neurons of the nucleus incertus and the hippocampal theta activity in the rat","authors":"S. Martínez-Bellver, A. Cervera-Ferri, Aina Luque‐García, J. Martínez-Ricós, A. Valverde-Navarro, M. Bataller, Juan Guerrero, V. Teruel-Martí","doi":"10.1113/JP272841","DOIUrl":null,"url":null,"abstract":"The nucleus incertus is a key node of the brainstem circuitry involved in hippocampal theta rhythmicity. Synchronisation exists between the nucleus incertus and hippocampal activities during theta periods. By the Granger causality analysis, we demonstrated a directional information flow between theta rhythmical neurons in the nucleus incertus and the hippocampus in theta‐on states. The electrical stimulation of the nucleus incertus is also able to evoke a phase reset of the hippocampal theta wave. Our data suggest that the nucleus incertus is a key node of theta generation and the modulation network.","PeriodicalId":22512,"journal":{"name":"The Japanese journal of physiology","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"29","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Japanese journal of physiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1113/JP272841","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 29
Abstract
The nucleus incertus is a key node of the brainstem circuitry involved in hippocampal theta rhythmicity. Synchronisation exists between the nucleus incertus and hippocampal activities during theta periods. By the Granger causality analysis, we demonstrated a directional information flow between theta rhythmical neurons in the nucleus incertus and the hippocampus in theta‐on states. The electrical stimulation of the nucleus incertus is also able to evoke a phase reset of the hippocampal theta wave. Our data suggest that the nucleus incertus is a key node of theta generation and the modulation network.