A phase II study of low-dose megestrol acetate using twice-daily dosing for anorexia in nonhormonally dependent cancer

K. Nelson, D. Walsh, M. Hussein
{"title":"A phase II study of low-dose megestrol acetate using twice-daily dosing for anorexia in nonhormonally dependent cancer","authors":"K. Nelson, D. Walsh, M. Hussein","doi":"10.1177/104990910201900313","DOIUrl":null,"url":null,"abstract":"Anorexia is a common problem in advanced cancer. Low-dose megestrol acetate, a semi-synthetic progesterone, given twice daily, is an effective appetite stimulant in advanced cancer patients. There was an excellent correlation between patient satisfaction and the primary response criteria (appetite improvement). Given cost, side-effect profile, ease of administration, and efficacy, 80 mg twice daily after meals is an appropriate starting dose of megestrol acetate for anorexia in advanced cancer. If this is not effective, considerable dose escalation is possible.","PeriodicalId":7716,"journal":{"name":"American Journal of Hospice and Palliative Medicine®","volume":"26 1","pages":"206 - 210"},"PeriodicalIF":0.0000,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Hospice and Palliative Medicine®","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/104990910201900313","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9

Abstract

Anorexia is a common problem in advanced cancer. Low-dose megestrol acetate, a semi-synthetic progesterone, given twice daily, is an effective appetite stimulant in advanced cancer patients. There was an excellent correlation between patient satisfaction and the primary response criteria (appetite improvement). Given cost, side-effect profile, ease of administration, and efficacy, 80 mg twice daily after meals is an appropriate starting dose of megestrol acetate for anorexia in advanced cancer. If this is not effective, considerable dose escalation is possible.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
低剂量醋酸甲地孕酮每日两次治疗非激素依赖性癌症患者厌食症的II期研究
厌食症是晚期癌症的常见问题。低剂量的醋酸甲孕酮是一种半合成的黄体酮,每天服用两次,对晚期癌症患者是一种有效的食欲兴奋剂。患者满意度与主要反应标准(食欲改善)之间存在极好的相关性。考虑到成本、副作用、给药的便捷性和疗效,80mg醋酸甲地孕酮餐后服用是治疗晚期癌症厌食症的合适起始剂量。如果不有效,可能会有相当大的剂量增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Association Between Oral Health Status and Survival Time in Terminally Ill Cancer Patients Hospice news 2005 Cumulative subject index Hospice news Call for manuscripts
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1