Many people are taking insulin-like growth factor-I without even knowing it.

J. Mercola, C. Mermer
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引用次数: 1

Abstract

To the editor, Adams does an excellent job of discussing the dangers of the exogenous augmentation of insulin-like growth factor-I (IGF-I) and properly cautions against its use, citing both lack of efficacy and potential adverse effects, such as disruption of the insulin system and carcinogenesis.1 However, many people in the United States are consuming higher levels of IGF-I than they realize and may face the same elevated risks because milk from cows treated with recombinant bovine growth hormone (rBGH) has significantly elevated IGF-I levels. Measuring these levels has even been proposed as a basis by which to test for the use of rBGH.2 In addition, the IGF-I in the milk of rBGH-treated cows is potentially more bioactive than the naturally occurring form, and this bioactivity may be increased further by pasteurization.3 Adams notes the lack of significant effects of IGF-I administration in the elderly, but this does not necessarily hold true for children, who may be at an increased risk of adverse effects. Children's rapid growth may make them more susceptible to IGF-I. In addition, children's intestines, particularly those of infants, are naturally more permeable than those in adults, which could allow greater absorption of the large IGF-I peptide. Despite the common assumption that IGF-I cannot be significantly absorbed when taken orally, several studies have shown that this is not the case. Premature babies given breast milk in addition to formula had almost twice the serum IGF-I levels of those receiving formula alone.4 This finding is not surprising because breast milk contains IGF-I and formula does not, but it does strongly suggest intestinal absorption. Furthermore, people who consumed 3 servings of milk daily had a 10% higher level of serum IGF-I and almost a 10% lower level of IGF binding protein-4 than people who drank less than 1.5 servings.5 Although healthy people may absorb only limited quantities of IGF-I, the situation is likely different for people with conditions that can cause increased intestinal permeability, such as celiac disease, Crohn's disease, autism, cirrhosis, and cow's milk allergy. The use of various medications, such as aspirin and other nonsteroidal anti-inflammatory drugs, can also increase intestinal permeability. In addition, an estimated 10% to 20% of the general “healthy” population unknowingly suffers from this condition.6 It is not enough to look at healthy adults and say that the intestinal absorption of IGF-I is negligible. Rather, the vulnerable in society need to be protected. Adams eloquently points out that the use of IGF-I for enhancing athletic performance “ignore[s] our understanding of the integrated nature of physiologic systems.”1 However, this same ignorance was used when the Food and Drug Adminstration chose to approve the use of rBGH. Let's not put corporate profits ahead of children's health. The use of growth hormones in livestock has certainly not been proven safe, and no overriding benefits would justify such risks.
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许多人在不知情的情况下服用了胰岛素样生长因子- 1。
对于编辑来说,Adams出色地讨论了外源性增加胰岛素样生长因子- i (IGF-I)的危险,并对其使用提出了适当的警告,指出其缺乏疗效和潜在的不良影响,如破坏胰岛素系统和致癌然而,在美国,许多人摄入的igf - 1水平比他们意识到的要高,并且可能面临同样高的风险,因为用重组牛生长激素(rBGH)处理过的奶牛的牛奶中igf - 1水平显著升高。测量这些水平甚至被提议作为测试rbgh使用情况的基础此外,经过rbgh处理的奶牛的牛奶中的igf - 1可能比自然存在的形式具有更高的生物活性,并且这种生物活性可能通过巴氏杀菌进一步提高亚当斯指出,igf - 1对老年人没有明显的作用,但对儿童却不一定如此,因为儿童可能面临更大的不良反应风险。儿童的快速生长可能使他们更容易受到igf - 1的影响。此外,儿童的肠道,尤其是婴儿的肠道,比成人的肠道具有更强的渗透性,这可以让大量的igf - 1肽被更多地吸收。尽管人们普遍认为口服igf - 1不能被显著吸收,但一些研究表明情况并非如此。除了配方奶外,母乳喂养的早产儿血清igf - 1水平几乎是只吃配方奶的早产儿的两倍这一发现并不令人惊讶,因为母乳不包含IGF-I和公式,但是强烈建议肠道吸收。此外,每天喝三份牛奶的人血清IGF- 1水平比每天喝不到1.5份牛奶的人高10%,IGF结合蛋白-4水平比每天喝不到1.5份牛奶的人低近10%虽然健康的人可能吸收只有数量有限的IGF-I,情况可能不同的情况下可能会导致患者肠道通透性增加,如乳糜泻、克罗恩病、自闭症、肝硬化,和牛奶过敏。使用各种药物,如阿司匹林和其他非甾体抗炎药,也可以增加肠道通透性。此外,据估计,一般"健康"人群中有10%至20%不知不觉地患有这种疾病仅仅观察健康的成年人就说igf - 1的肠道吸收微不足道是不够的。相反,社会中的弱势群体需要得到保护。亚当斯雄辩地指出,使用igf - 1来提高运动成绩“忽略了我们对生理系统综合本质的理解。然而,当食品和药物管理局选择批准使用rBGH时,同样的无知也被使用了。我们不能把企业利润置于儿童健康之上。在牲畜中使用生长激素当然还没有被证明是安全的,没有任何压倒性的好处可以证明这样的风险是合理的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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