The geometric framework: An approach for studying the impact of nutrition on healthy aging

Q3 Pharmacology, Toxicology and Pharmaceutics Drug Discovery Today: Disease Models Pub Date : 2018-03-01 DOI:10.1016/j.ddmod.2019.03.002

Samantha M. Solon-Biet , Devin Wahl , David Raubenheimer , Victoria C. Cogger , David G. Le Couteur , Stephen J. Simpson

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引用次数: 5

Abstract

The most robust interventions that impact on the biological processes of aging and age-related diseases are nutritional (caloric restriction, protein restriction, intermittent fasting) or those pharmacological and genetic interventions that act on nutrient sensing pathways. The best established nutritional intervention is caloric restriction, but this is not feasible in most humans; therefore, other nutritional interventions that influence aging but do not involve protracted periods of fasting have been studied. The Geometric Framework provides a powerful research tool for disentangling the effects of various nutrients and calorie intake, in both restricted and ad libitum-fed diets, on phenotypic outcomes such as aging and lifespan. This approach can also be applied to understanding the complex network of nutrient sensing pathways, potentially identifying new targets for the development of drugs that influence healthy aging.

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几何框架:一种研究营养对健康老龄化影响的方法

对衰老和与年龄有关的疾病的生物过程产生影响的最有力的干预措施是营养(热量限制、蛋白质限制、间歇性禁食)或作用于营养感知途径的药理学和遗传干预措施。目前公认的最佳营养干预措施是限制热量摄入，但这对大多数人来说并不可行;因此，其他影响衰老但不涉及长时间禁食的营养干预措施已被研究。几何框架提供了一个强大的研究工具，用于解开各种营养和卡路里摄入对表型结果(如衰老和寿命)的影响，包括限制和自由喂养的饮食。这种方法也可以应用于理解营养感知途径的复杂网络，潜在地确定影响健康衰老的药物开发的新靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.