Correlation of Vertical Cup Disc Ratio and Matrix FDT Mean Deviation in Primary Open Angle Glaucoma Patients

Nathaniel Godswill Inye, Pepple Godswill
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Abstract

Objectives: To evaluate the correlation between glaucomatous structural change using vertical-cup-disc ratio of the optic nerve head and functional loss measured by Frequency Doubling Technology perimetry. Materials and methods: It was a retrospective observational clinic-based study of 77 newly diagnosed Primary Open Angle Glaucoma (POAG) patients from a Private Eye clinic in a suburb of Port Harcourt city, Nigeria. They underwent clinical fundal examination with slit-lamp biomicroscope (Perkin’s slit-lamp) with 90D (Volk) lens; and Frequency Doubling Technology perimetry 24-2 threshold (Humphrey Matrix 800, 2011 Carl Zeiss Meditec, Dublin, California). The Vertical-cup-disc-ratio was assessed for each eye and the Mean deviation calculated for each eye. The relationship between VCDR and mean deviation was evaluated using Pearson’s correlation coefficient regression analysis. Result: There were 24 males (31.17%) and 53 females (68.83%). The mean age of the patients was 56.65 ± 14.33 years with a range of 37-78 years. The mean VCDR was 0.83±0.09 and 0.78±0.13 for the right and left eyes, respectively while mean FDT mean deviation was -13.99±9.33Db and -11.9.22Db for the right and left eyes, respectively. The VCDR significantly correlated with FDT mean deviation (Pearson Correlation Coefficient, r= -0.923, r2= 0.852, p-value=0.001 for the right eye; r= -0.915, r2=0.836, p-value=0.001 for the left eye. Conclusion: This study shows that at least 80% of VCDR correlated with the Mean deviation of matrix FDT amongst this cohort of POAG patients. it buttresses the fact that clinical evaluation of the optic nerve remains an indispensable tool in glaucoma diagnosis and can use to assess glaucoma severity in resource poor setting where visual field machine is not available.
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原发性开角型青光眼患者垂直杯盘比与基质FDT平均偏差的相关性
目的:探讨视神经头垂直杯盘比测定的青光眼结构改变与倍频技术视野测量的功能丧失的相关性。材料和方法:对尼日利亚哈科特港郊区一家私人眼科诊所77例新诊断的原发性开角型青光眼(POAG)患者进行回顾性临床观察研究。采用90D (Volk)晶状体的裂隙灯生物显微镜(Perkin 's裂隙灯)进行临床基础检查;倍频技术视界24-2阈值(Humphrey Matrix 800, 2011年Carl Zeiss Meditec, Dublin, California)。评估每只眼的垂直杯盘比,计算每只眼的平均偏差。采用Pearson相关系数回归分析评价VCDR与平均偏差的关系。结果:男性24例(31.17%),女性53例(68.83%)。患者平均年龄56.65±14.33岁,年龄范围37 ~ 78岁。右眼和左眼的平均VCDR分别为0.83±0.09和0.78±0.13,右眼和左眼的平均FDT平均偏差分别为-13.99±9.33Db和-11.9.22Db。右眼VCDR与FDT平均偏差显著相关(Pearson相关系数,r= -0.923, r2= 0.852, p值=0.001);左眼R = -0.915, r2=0.836, p值=0.001。结论:本研究表明,在该队列POAG患者中,至少80%的VCDR与基质FDT的平均偏差相关。它支持这样一个事实,即视神经的临床评估仍然是青光眼诊断中不可或缺的工具,并且可以用于评估资源贫乏的环境中没有视野机的青光眼严重程度。
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