Qualitative Assessment of a Customized Anti-hepatic Herbal Formulation in Bangladesh

Dhaka University Journal of Pharmaceutical Sciences Pub Date : 2022-06-26 DOI:10.3329/dujps.v21i1.60397

Md. Hafizur Rahman, B. Rokeya, M. Mosihuzzaman, Md. Shahinul Haque Khan

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引用次数: 1

Abstract

Qualitative assessment of herbal formulations is used in pre-health care of many diseases. The potency, composition and safety of herbal formulation are serious concerns in Bangladesh. Therefore, the aim of the present study was to evaluate the qualitative assessment of a customized anti-hepatic herbal formulation in Bangladesh. Isolation of compounds, toxic metals analysis, phytochemical screening, microbial test and determination of SGPT and SGOT level of hepatic model rats were focused in this study. The phytochemical screening revealed the presence of phenol, saponins and tannins. In chemical study, four known compounds were isolated from the formulation (Sodium benzoate, methyl-4-hydroxybenzoate, 4-hyroxybenzaldehyde and 4-hydroxy- 3-methoxybenzaldehyde). The results of microbial purity and toxic metals analysis were in favorable limit although the levels of SGOT and SGPT were raised non-significantly. So, based on the study it has been concluded that quality assessment is urgently required for this type of customized herbal formulations. Dhaka Univ. J. Pharm. Sci. 21(1): 59-67, 2022 (June)

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孟加拉国定制抗肝草药配方的定性评估

草药配方的定性评估用于许多疾病的保健前。草药配方的效力、成分和安全性是孟加拉国严重关切的问题。因此，本研究的目的是评估孟加拉国定制抗肝草药配方的定性评估。本研究的重点是化合物的分离、有毒金属分析、植物化学筛选、微生物试验以及肝模型大鼠SGPT和SGOT水平的测定。植物化学筛选显示酚、皂苷和单宁的存在。在化学研究中，从该配方中分离到4个已知化合物(苯甲酸钠、4-羟基苯甲酸甲酯、4-羟基苯甲醛和4-羟基- 3-甲氧基苯甲醛)。微生物纯度和有毒金属分析结果良好，但SGOT和SGPT水平无显著升高。因此，在研究的基础上得出结论，迫切需要对这类定制草药配方进行质量评价。达卡大学药学院。科学21(1):59-67,2022 (6)

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Dhaka University Journal of Pharmaceutical Sciences

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