Efficacy and Safety of a Natural Supplement Containing Serenoa Repens, Solanum Lycopersicum, Lycopene, and Bromelain in Reducing Symptoms of Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Prospective Cohort Study in 250 Patients

IF 0.4 Q4 MATHEMATICS, APPLIED Trudy Instituta Matematiki i Mekhaniki UrO RAN Pub Date : 2023-07-20 DOI:10.3390/uro3030021
L. Lambertini, Alessandro Sandulli, Vincenzo Salamone, M. Bacchiani, S. Giudici, Eleana Massaro, A. Cadenar, R. Mariottini, Simone Coco, Laia Bardina, Elena Ciaralli, Marco Saladino, A. Romano, F. Valastro, A. Grosso, F. di Maida, G. Siena, S. Scelzi, A. Mari
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Abstract

Background: Chronic Prostatitis/Chronic Pelvic Pain syndrome NIH-class III is a widespread condition affecting men universally, with existing treatments showing limited success. This study evaluated the efficacy and safety of a natural supplement, composed of Serenoa repens, Solanum lycopersicum, lycopene, and bromelain, in managing symptoms of this condition among a substantial patient group. Methods: In this prospective study, 245 patients diagnosed with Chronic Prostatitis/Chronic Pelvic Pain syndrome NIH-class III were treated with the aforementioned supplement, alongside lifestyle alterations, such as refraining from spicy foods, alcohol, caffeine, and cycling, for a duration of three months. Patients’ progress was assessed at one and three months using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Index (IPSS), quality of life (QoL) scores, and changes in total prostate-specific antigen (PSA) levels. Results: The supplement was well received with no serious adverse events reported. Significant improvements were observed in NIH-CPSI scores, IPSS, QoL scores, and a substantial decrease in total PSA levels at three months compared to baseline, with a positive trend noted from one-month to three-month evaluations. This was consistent in either patients with predominantly voiding or storage urinary symptoms. Conclusions: Our results suggest that this natural supplement in conjunction with lifestyle changes could offer a safe and effective alternative treatment for patients suffering from Chronic Prostatitis/Chronic Pelvic Pain syndrome NIH-class III. However, these findings require validation through further large-scale randomized controlled trials.
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含有藜麦、番茄茄、番茄红素和菠萝蛋白酶的天然补充剂减轻慢性前列腺炎/慢性盆腔疼痛综合征症状的有效性和安全性:250例患者的前瞻性队列研究
背景:慢性前列腺炎/慢性盆腔疼痛综合征(NIH-class III)是一种普遍影响男性的广泛疾病,现有治疗效果有限。本研究评估了一种天然补充剂的有效性和安全性,该补充剂由藜麦、番茄茄、番茄红素和菠萝蛋白酶组成,在大量患者组中控制这种疾病的症状。方法:在这项前瞻性研究中,245名诊断为慢性前列腺炎/慢性盆腔疼痛综合征(NIH-class III)的患者接受上述补充剂治疗,同时改变生活方式,如避免辛辣食物、酒精、咖啡因和骑自行车,持续三个月。采用美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)、国际前列腺症状指数(IPSS)、生活质量(QoL)评分和总前列腺特异性抗原(PSA)水平的变化,在1个月和3个月时评估患者的进展。结果:本品效果良好,无严重不良事件报告。在NIH-CPSI评分、IPSS评分、生活质量评分中观察到显著改善,与基线相比,三个月时总PSA水平显著下降,从一个月到三个月的评估中发现积极趋势。这在以排尿或储尿症状为主的患者中是一致的。结论:我们的研究结果表明,这种天然补充剂结合生活方式的改变,可以为慢性前列腺炎/慢性盆腔疼痛综合征(NIH-class III)患者提供安全有效的替代治疗。然而,这些发现需要通过进一步的大规模随机对照试验来验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
0.80
自引率
20.00%
发文量
67
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