In vitroantiparasitic and antibacterial evaluation of organic extracts of Salvadoran flora

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-30 DOI:10.37360/blacpma.23.22.1.2

Marvin J. Núñez, Alma D. Paz-González, Lenci K. Vázquez-Jiménez, Ulises G. Castillo, R. Moo-Puc, Jesús M. Chan-Bacab, Guadalupe Aguilera-Arreola, Lucero Catalán-Gonzalez, Alexis Uriel Quintana-Gómez, Jorge Ismael Castañeda-Sánchez, Julieta Luna-Herrera, G. Rivera

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Abstract

Currently, in developing countries, parasitic and bacterial diseases as amebiasis, giardiasis, trichonomiasis, leishmaniasis, trypanosomiasis, tuberculosis, and nocardiasis are a public health problem. The pharmacological treatment for these diseases is not completely effective and causes several side effects in patients. Therefore, the searchfor new compounds with biological activity is very important to develop new drugs safely and more efficiently. In this study, different organic extracts obtained from thirty-seven species of the Salvadoran flora were evaluated in several in vitromodels to determine their potential activity against five protozoa (Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Leishmania mexicana, and Trypanosoma cruzi) and three bacteria (Acinetobacter baumanni, Mycobacterium tuberculosis, and Nocardia brasiliensis). The results showed the activity of eight extracts with IC50values of less than 100 μg/mL against L. mexicanaand five extracts with MICs values less than <50 μg/mL against M. tuberculosis. Besides, seven plant species showed MICs ≤3.125 μg/mL against N. brasiliensis. Additionally, secondary metabolites (flavonoids and monoterpene oxygenate) previously reported as active were fingerprint by UPLC-MS to establish a potential correlation with the biological activity showed.

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萨尔瓦多植物有机提取物体外抗寄生虫及抗菌评价

目前，在发展中国家，阿米巴病、贾第虫病、滴虫病、利什曼病、锥虫病、结核病和诺卡病等寄生虫和细菌性疾病是一个公共卫生问题。对这些疾病的药物治疗并不完全有效，并对患者造成一些副作用。因此，寻找具有生物活性的新化合物对于安全高效地开发新药具有十分重要的意义。在这项研究中，从萨尔瓦多37种植物中获得的不同有机提取物在几个体外模型中进行了评估，以确定其对五种原生动物(溶组织内阿米巴原虫、兰贾第鞭毛虫、阴道毛滴虫、墨西哥利什曼原虫和克氏锥虫)和三种细菌(鲍曼不动杆菌、结核分枝杆菌和巴西诺卡菌)的潜在活性。结果表明，8个提取物对墨西哥乳杆菌的ic50值小于100 μg/mL, 5个提取物对结核分枝杆菌的ic50值小于50 μg/mL。7种植物对巴西乳螨的mic值≤3.125 μg/mL。此外，利用UPLC-MS对先前报道的次生代谢产物(黄酮类化合物和单萜氧合物)进行指纹图谱分析，以建立与生物活性的潜在相关性。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.