Comparison of Disintegration Time of Coated Tablets in Test Fluids of Different pH Values

Abstract

Disintegration tests of coated tablets were carried out in immersion fluids of different pH values according to the modified procedure described in the Japanese Pharmacopoeia (J.P.). The apparatus used was also conformed to J. P. Consequently, 134 of 141 samples were completely disintegrated in any of the acidic fluids. But, 5 of them were not always disintegrated in such test fluids, and 2 were disintegrated by the methods other than those described in J. P. The official compendium and package inserts now in use should be supplemented with more data on disintegration.