Galectin-3 as a prognostic biomarker for diabetic nephropathy

N. Mohamed, N. Marie, Wagida Abouraya, Salwa El Shennawy, S. Mahmoud
{"title":"Galectin-3 as a prognostic biomarker for diabetic nephropathy","authors":"N. Mohamed, N. Marie, Wagida Abouraya, Salwa El Shennawy, S. Mahmoud","doi":"10.4103/sjamf.sjamf_244_21","DOIUrl":null,"url":null,"abstract":"Background Diabetes mellitus (DM) type 2 is a major health condition that has shown an increased incidence globally. The most common complication in type 2 DM is diabetic nephropathy (DN). Aim To determine serum galectin-3 as a prognostic biomarker in type 2 DN. Patients and methods A case–control prospective study was done in the Internal Medicine Department of AL-Zahraa University Hospital, Cairo, Egypt. The study was conducted on 90 patients, including 60 patients with type 2 DM and 30 age-matched and sex-matched healthy volunteers as a control group. The 90 patients were classified into four groups: group I included 20 diabetic patients (type 2) with an albumin/creatinine ratio (ACR) of less than 30 mg/g (normoalbuminuria), group II included 20 DM (type 2) with an ACR of 30–300 mg/g (microalbuminuria), group III included 20 DM (type 2) with an ACR of more than 300 mg/g (macroalbuminuria), and control group included 30 age-matched and sex-matched healthy individuals. History, examination, fasting blood sugar, glycated hemoglobin, urea, creatinine, estimated glomerular filtration rate, ACR, lipid profile, and serum galectin-3 were done for all participants. The study was approved by the Al Azhar University Ethics Board. Results Galectin-3 was significantly higher in patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria. Galectin-3 level has a significant positive correlation with parameters of DN progression (age, DM duration, fasting blood sugar, glycated hemoglobin, cholesterol, low-density lipoprotein, triglyceride, urea, creatinine, and ACR) and a significant negative correlation with estimated glomerular filtration rate and high-density lipoprotein levels. Conclusion Galectin-3 was significantly higher in type 2 diabetic patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria.","PeriodicalId":22975,"journal":{"name":"The Scientific Journal of Al-Azhar Medical Faculty, Girls","volume":"24 1","pages":"44 - 50"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Scientific Journal of Al-Azhar Medical Faculty, Girls","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/sjamf.sjamf_244_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background Diabetes mellitus (DM) type 2 is a major health condition that has shown an increased incidence globally. The most common complication in type 2 DM is diabetic nephropathy (DN). Aim To determine serum galectin-3 as a prognostic biomarker in type 2 DN. Patients and methods A case–control prospective study was done in the Internal Medicine Department of AL-Zahraa University Hospital, Cairo, Egypt. The study was conducted on 90 patients, including 60 patients with type 2 DM and 30 age-matched and sex-matched healthy volunteers as a control group. The 90 patients were classified into four groups: group I included 20 diabetic patients (type 2) with an albumin/creatinine ratio (ACR) of less than 30 mg/g (normoalbuminuria), group II included 20 DM (type 2) with an ACR of 30–300 mg/g (microalbuminuria), group III included 20 DM (type 2) with an ACR of more than 300 mg/g (macroalbuminuria), and control group included 30 age-matched and sex-matched healthy individuals. History, examination, fasting blood sugar, glycated hemoglobin, urea, creatinine, estimated glomerular filtration rate, ACR, lipid profile, and serum galectin-3 were done for all participants. The study was approved by the Al Azhar University Ethics Board. Results Galectin-3 was significantly higher in patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria. Galectin-3 level has a significant positive correlation with parameters of DN progression (age, DM duration, fasting blood sugar, glycated hemoglobin, cholesterol, low-density lipoprotein, triglyceride, urea, creatinine, and ACR) and a significant negative correlation with estimated glomerular filtration rate and high-density lipoprotein levels. Conclusion Galectin-3 was significantly higher in type 2 diabetic patients with macroalbuminuria than in those with microalbuminuria and normoalbuminuria.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
半乳糖凝集素-3作为糖尿病肾病的预后生物标志物
背景2型糖尿病(DM)是一种主要的健康状况,在全球范围内发病率呈上升趋势。2型糖尿病最常见的并发症是糖尿病肾病(DN)。目的探讨血清半乳糖凝集素-3在2型DN患者预后中的作用。患者和方法在埃及开罗AL-Zahraa大学医院内科进行了一项病例对照前瞻性研究。该研究对90名患者进行了研究,其中包括60名2型糖尿病患者和30名年龄和性别匹配的健康志愿者作为对照组。90例患者分为4组:1组20例糖尿病患者(2型),白蛋白/肌酐比值(ACR)小于30mg /g(正常白蛋白尿),2组20例糖尿病患者(2型),ACR为30 - 300mg /g(微量白蛋白尿),3组20例糖尿病患者(2型),ACR大于300mg /g(大量白蛋白尿),对照组30例年龄匹配和性别匹配的健康个体。对所有参与者进行病史、检查、空腹血糖、糖化血红蛋白、尿素、肌酐、肾小球滤过率、ACR、血脂和血清半乳糖凝集素-3的评估。这项研究得到了爱资哈尔大学伦理委员会的批准。结果半乳糖凝集素-3在大量蛋白尿患者中的含量明显高于微量蛋白尿和正常蛋白尿患者。半乳糖凝集素-3水平与DN进展参数(年龄、DM病程、空腹血糖、糖化血红蛋白、胆固醇、低密度脂蛋白、甘油三酯、尿素、肌酐、ACR)呈显著正相关,与肾小球滤过率和高密度脂蛋白水平呈显著负相关。结论2型糖尿病伴大量白蛋白尿患者半乳糖凝集素-3水平明显高于伴少量白蛋白尿和正常白蛋白尿患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Evaluation of nanofat injection in postburn and post-traumatic facial scars Immunological markers changes in pediatric immune Thrombocytopenic Purpura Minimally invasive strabismus surgery versus paralimbal approach for horizontal strabismus surgery Clinical applications of brain diffusion-tensor imaging and fiber tractography Choroidal and retinal nerve fiber layer thicknesses in smokers
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1