Recent advances in the biological activity of quinazoline

S. Nagrale, Amit Pondkule, V. Babar
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Abstract

The aim of this review is to produce an outline of numerous pharmacologic activities of quinazoline moiety. Quinazoline has become a famous topic up of two fused six-membered simple aromatic rings, a benzene ring and a pyrimidine ring because of its manifold uses. various quinazoline derivatives have been found to gives a broad spectrum of biological activities, which stimulated the research activity in this field. Quinazolines and its derivatives represent one in all the foremost active categories of compounds, that possess wide selection of biological activities like anti-bacterial, analgesic, anti-microbial, anti-inflammatory drug, anticancer, and anti-hypertensive, antifungal, anti-HIV, inhibitor, analgesic, medicament, antiprotozoal, antitumor, anti-tubercular activities. This review is an effort to magnify the immense potentiality of this ring system. This study may accelerate the designing process to come up with a lot of range of therapeutically viable clinical candidates.
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喹唑啉生物活性研究进展
本文综述了喹唑啉部分的多种药理活性。喹唑啉由于其广泛的用途,已成为一个由苯环和嘧啶环两个六元简单芳香环融合而成的著名课题。各种喹唑啉衍生物被发现具有广泛的生物活性,这刺激了这一领域的研究活动。喹唑啉类化合物及其衍生物具有抗菌、镇痛、抗微生物、抗炎、抗癌、降压、抗真菌、抗hiv、抑制剂、镇痛、药物、抗原虫、抗肿瘤、抗结核等多种生物活性,是一类最具活性的化合物。这篇评论是为了放大这一环系统的巨大潜力。这项研究可能会加速设计过程,以提出许多治疗上可行的临床候选药物。
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