{"title":"Platelet yield varies but in vitro function is maintained after leukocyte removal using terumo imugard™ filter and cutter Leukotrap™","authors":"A. Gerber, U.E. Nydegger","doi":"10.1016/S0278-6222(87)80051-7","DOIUrl":null,"url":null,"abstract":"<div><p>In order to investigate whether current leukocyte-removing techniques have an influence on functional performance of platelets in vitro, we carried out white blood cell (WBC) removal procedures on 24 clinically prescribed platelet concentrates, 12 of them with Imugard IG-500™ cotton wool filter and 12 with centrifugation in the Leukotrap™ bag. Samples were obtained from the platelet concentrates before and subsequent to leukocyte removal and, after assessment of the platelet yield rate, tested by means of <sup>14</sup>C-serotonin-uptake and aggregation response towards collagen and adrenaline. Neither test system indicated significant loss of platelet function regardless of the leukocyte-removing technique used. Mean platelet yield rate in the IG-500™ group was 86% (SD ± 8.4) compared with 77% (SD ± 6.1) in the group processed with Leukotrap™ (<em>P</em> < 0.01).</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 396-403"},"PeriodicalIF":0.0000,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80051-7","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasma Therapy and Transfusion Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0278622287800517","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In order to investigate whether current leukocyte-removing techniques have an influence on functional performance of platelets in vitro, we carried out white blood cell (WBC) removal procedures on 24 clinically prescribed platelet concentrates, 12 of them with Imugard IG-500™ cotton wool filter and 12 with centrifugation in the Leukotrap™ bag. Samples were obtained from the platelet concentrates before and subsequent to leukocyte removal and, after assessment of the platelet yield rate, tested by means of 14C-serotonin-uptake and aggregation response towards collagen and adrenaline. Neither test system indicated significant loss of platelet function regardless of the leukocyte-removing technique used. Mean platelet yield rate in the IG-500™ group was 86% (SD ± 8.4) compared with 77% (SD ± 6.1) in the group processed with Leukotrap™ (P < 0.01).
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