M. Adami, S. Bertini, P. Frati, G. Soldani, G. Coruzzi
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引用次数: 5
Abstract
The effects of cannabinoid CB1 receptor activation (HU-210) and blockade (SR141716A) on gastric acid secretion were determined in anaesthetized rats with lumen perfused stomach. The selective CB1-receptor agonist HU-210 (0.01-0-1 mg kg−1, i.v.) did not affect basal acid secretion while causing inhibition (maximum reduction 74%) of the gastric acid secretion stimulated by pentagastrin (10μ kg−1, i.v.).
The inhibitory effect of HU-210 was reversed by the selective cannabinoid CB1-receptor antagonist SR141716A (1 mg kg−1, i.v.), but not by the selective CB2-receptor antagonist SR144528 (1 mg kg−1, i.v.).
These results suggest that cannabinoid CB1 receptors may mediate inhibitory effects on gastric acid secretion in the rat.
研究了大麻素CB1受体激活(HU-210)和阻断(SR141716A)对麻醉胃腔灌注大鼠胃酸分泌的影响。选择性cb1受体激动剂HU-210 (0.01-0-1 mg kg -1，静脉注射)不影响基底酸分泌，但对戊胃泌素(10μ kg -1，静脉注射)刺激的胃酸分泌有抑制作用(最大减少74%)。HU-210的抑制作用被选择性大麻素cb1受体拮抗剂SR141716A (1 mg kg - 1，静脉注射)逆转，但不被选择性cb2受体拮抗剂SR144528 (1 mg kg - 1，静脉注射)逆转。提示大麻素CB1受体可能介导大鼠胃酸分泌的抑制作用。
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