Monocytes in tumor: from the sight of Single-cell analysis

Tumor discovery Pub Date : 2022-03-10 DOI:10.36922/td.v1i1.4
Xin Fu, Mingzhu Yin
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引用次数: 1

Abstract

Mononuclear phagocytes infiltration in the tumor microenvironment orchestra the tumor progression and are generally considered to impede the clinical effects of immune checkpoint blockade therapies. To overcome the traditional biased definition of monocytes, we reviewed some recent advances on the functions of monocytes and macrophages in tumor microenvironment based on single-cell analysis. We also summarized different subpopulations of monocytes and macrophages involved in immunotherapies and their potential applications in clinical study. In this script, we briefly introduce the developmental trajectory of mononuclear phagocytes, including monocytes, tumor associated macrophages (TAMs), DCs, myeloid-derived suppressive cells (MDSC) and their multiple functions in TME. We demonstrate the potential of monocytes and its derived cells being diagnostic and therapeutic targets, especially highlight the interaction between monocytes and immune checkpoint therapies.
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肿瘤中的单核细胞:从单细胞的角度分析
肿瘤微环境中的单核吞噬细胞浸润控制肿瘤的进展,通常被认为会阻碍免疫检查点阻断疗法的临床效果。为了克服传统的单核细胞定义的偏见,我们基于单细胞分析综述了单核细胞和巨噬细胞在肿瘤微环境中功能的最新进展。我们还总结了参与免疫治疗的单核细胞和巨噬细胞的不同亚群及其在临床研究中的潜在应用。在本文中,我们简要介绍了单核吞噬细胞的发育轨迹,包括单核细胞、肿瘤相关巨噬细胞(tam)、dc、髓源性抑制细胞(MDSC)及其在TME中的多种功能。我们展示了单核细胞及其衍生细胞作为诊断和治疗靶点的潜力,特别强调了单核细胞和免疫检查点疗法之间的相互作用。
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