Review on Some Biochemical markers in mMetabolic-Associated Fatty Liver Disease

Abstract

Liver is a primary organ for lipid and glucose homeostasis and is the focus of cardio metabolic disease. The  NAFLD definition is combines the existence of steatosis in more than 5% of hepatocytes and metabolic risk factors, particularly obesity and T2DM, and exclusion of excessive alcohol consumption defined as ? 30 g per day for men and ? 20 g per day for women, or other chronic liver diseases  In  2020,  it was  suggest that the nomenclature of nonalcoholic fatty liver disease (NAFLD) should be updated to metabolic-associated fatty liver disease  (MAFLD),   Also it was found the diagnosis of MAFLD should be based on the presence of metabolic dysfunction not the absence of other conditions ,  MAFLD can coexist with other liver diseases and A reference to alcohol should not be included in the MAFLD acronym. Biochemical parameters play a significant role in careful diagnosis and also for risk assessment and adopting treatment that improves clinical outcome.  In this article, we will highlight the nomenclature and diagnosis of metabolic-associated fatty liver disease which before 2020 was called non-alcoholic fatty liver disease, and explain some of the biochemical parameters in this disease.