{"title":"Possible Role for Hepcidin in Acute Neuroleptic Malignant Syndrome","authors":"R. Gurrera","doi":"10.4172/2168-975X.1000216","DOIUrl":null,"url":null,"abstract":"Acute reductions in serum iron levels are frequently associated with neuroleptic malignant syndrome (NMS) and have been implicated in the progression of catatonia to NMS. Iron catalyzes dopamine synthesis through its role as a cofactor for tyrosine hydroxylase, and modulates expression of the dopamine (D2) receptor and dopamine transporter proteins.","PeriodicalId":9146,"journal":{"name":"Brain disorders & therapy","volume":"26 1","pages":"0-0"},"PeriodicalIF":0.0000,"publicationDate":"2016-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain disorders & therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2168-975X.1000216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Acute reductions in serum iron levels are frequently associated with neuroleptic malignant syndrome (NMS) and have been implicated in the progression of catatonia to NMS. Iron catalyzes dopamine synthesis through its role as a cofactor for tyrosine hydroxylase, and modulates expression of the dopamine (D2) receptor and dopamine transporter proteins.
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