Adaptogens as potential drugs for prevention of infectious diseases

Abstract

The work is devoted to the analysis of scientific research on the prevention of infectious diseases by adaptogens, proposed by a prominent domestic toxicologist and pharmacologist Professor Nikolai Vasilyevich Lazarev and the school of scientists he created. The role of adaptogens (dibazol, Eleutherococcus, Rhodiola rosea, Scutellaria Baicalensis) in creating a state of non-specifically increased body resistance (NSIBR according to N.V. Lazarev) for the prevention of viral diseases, including coronavirus infection, was evaluated. Analysis of the pharmacological properties of the synthetic adaptogen bendazol (dibazol) opened by N.V. Lazarev, showed that the drug has a number of positive properties: antiviral stimulates immunity to the attack of infectious agents, being an inducer of endogenous interferon; antiproliferative inhibits the replication of viruses inside the host cell; immunomodulatory corrects violations of the protective functions of the body. Dibazol also has a mild effect after vaccination, stimulating the production of immunoglobulins. These properties of dibazol make it possible to recommend it and herbal adaptogens (tinctures of Eleutherococcus, Rhodiola rosea, Scutellaria Baicalensis) for the prevention of coronavirus infection.