Survival of white blood cells of mice (Mus musculus L) on interval AD with CD post gamma radiation Co-60

Abstract

One of the phenomena of the low-dose radiation effect is the radio adaptation response which is an important part of the response of molecules, cells, and body tissues to ionizing radiation. The phenomenon of radio adaptation response is a response that occurs when changes in gene expression can be induced by exposure to low doses of radiation (<0.5 Gy). Changes in the expression of this gene under certain circumstances serve to protect cells against the effects caused by subsequent exposure to higher doses of radiation, so this situation is known as an adaptive response or radio adaptation response. Cells can respond to very low doses of radiation with some changes in gene expression. Beginning with the administration of radiation to cells with a very low dose, known as the adaptation dose (AD), and then in a short period being given a larger dose of radiation, known as the challenge dose (CD), there was a decrease in the number of induced chromosome aberrations when compared to cells that were not irradiated at an adapted dose. The purpose of this study was to obtain a radiotherapy method that could show a reduction in the patient's dose.