Assigning the components of a Self-Nanoemulsifying Drug Delivery System (SNEDDs) of Deferasirox

Abstract

Deferasirox (DFR) is an oral tridentate iron chelator effective for reduction of body iron in ironoverloaded patients with transfusion-dependent anemias [1]. It is a highly lipophilic molecule (log P: 3.52) which is classified as BCS Class II drug substance [2]. Self-nanoemulsifying drug delivery systems (SNEDDs) are isotropic mixtures of drug, oil and hydrophilic surfactants and co-surfactant/co-solvents. In recent years, SNEDDs gained more attention in the solubility enhancement of lipophilic molecule hence enhancing their oral bioavailability. The selection of appropriate components in the SNEDDs formulation is crucial for development of a successful formulation. The goal of this work is to select and to screen appropriate components for the optimization of DFR loaded SNEDDs formulations. In this respect, different SNEDDs formulations were prepared and pseudo-ternary phase diagrams were constructed. 2. Materials and Methods