Microwave-promoted multi-component and green synthesis of thiadiazolo[3,2-a]pyrimidines under solvent-free conditions

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Chemical Sciences Pub Date : 2023-09-04 DOI:10.1007/s12039-023-02217-7

Behjat Pouramiri, Mohsen Rashidi

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Abstract

This research is aimed at synthesizing pyrimidine heterocycles that contain 1,3,4-thiadiazole ring moiety by microwave-assisted multi-component reactions. For this purpose, synthesizing of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate, and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1 respectively) in the presence of [Et₃NH]⁺[HSO₄]^- ionic liquid, under solvent-free conditions.

Graphical abstract

This research, synthesis of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1, respectively) in the presence of [Et₃NH]⁺[HSO₄]^- ionic liquid under solvent-free microwave irradiation.

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无溶剂条件下微波促进多组分噻二唑[3,2-a]嘧啶的绿色合成

本研究旨在利用微波辅助多组分反应合成含有1,3,4-噻二唑环的嘧啶杂环。为此，在无溶剂条件下，以芳香醛、乙酰乙酸乙酯和不同的1,3,4-噻二唑衍生物(摩尔比分别为1:2:1)为原料，在[Et3NH]+[HSO4]-离子液体存在下，一步反应合成了[1,3,4]噻二唑[3,2-a]嘧啶-6-羧酸衍生物。摘要本研究在无溶剂微波辐射下，以芳香醛、乙酰乙酸乙酯和不同的1,3,4-噻二唑衍生物(摩尔比分别为1:2:1)为原料，在[Et3NH]+[HSO4]-离子液体存在下，一步反应合成了[1,3,4]噻二唑[3,2-a]嘧啶-6-羧酸衍生物。

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.