B. Szende, L. Kisfaludy, K. Lapis, L. Dénes, L. Szporny, O. Nyéke, I. Schön, G. Hajos, J. Ember, M. Constantin
{"title":"The effect of TP-5 and its analogs on skin grafts in mice.","authors":"B. Szende, L. Kisfaludy, K. Lapis, L. Dénes, L. Szporny, O. Nyéke, I. Schön, G. Hajos, J. Ember, M. Constantin","doi":"10.3109/08923978509026470","DOIUrl":null,"url":null,"abstract":"The immunostimulatory action of oligopeptides RGH-0205 (Arg-Lys-Asp), RGH-0206 (Arg-Lys-Asp-Val) and TP-5 (Arg-Lys-Asp-Val-Try) was measured using the B10LP to C57BL skin graft system and the determination of splenic T cell ratio. While thymectomy increased the period between skin grafting and rejection, each of the oligopeptides increased the number of splenic T cells and in some extent restored the rejection capacity of thymectomised C57Bl mice, presumably by restoration of thymic hormone function.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"125 1","pages":"67-78"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of immunopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/08923978509026470","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
The immunostimulatory action of oligopeptides RGH-0205 (Arg-Lys-Asp), RGH-0206 (Arg-Lys-Asp-Val) and TP-5 (Arg-Lys-Asp-Val-Try) was measured using the B10LP to C57BL skin graft system and the determination of splenic T cell ratio. While thymectomy increased the period between skin grafting and rejection, each of the oligopeptides increased the number of splenic T cells and in some extent restored the rejection capacity of thymectomised C57Bl mice, presumably by restoration of thymic hormone function.