The effect of TP-5 and its analogs on skin grafts in mice.

B. Szende, L. Kisfaludy, K. Lapis, L. Dénes, L. Szporny, O. Nyéke, I. Schön, G. Hajos, J. Ember, M. Constantin
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引用次数: 3

Abstract

The immunostimulatory action of oligopeptides RGH-0205 (Arg-Lys-Asp), RGH-0206 (Arg-Lys-Asp-Val) and TP-5 (Arg-Lys-Asp-Val-Try) was measured using the B10LP to C57BL skin graft system and the determination of splenic T cell ratio. While thymectomy increased the period between skin grafting and rejection, each of the oligopeptides increased the number of splenic T cells and in some extent restored the rejection capacity of thymectomised C57Bl mice, presumably by restoration of thymic hormone function.
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TP-5及其类似物对小鼠皮肤移植的影响。
采用B10LP - C57BL皮肤移植系统和脾T细胞比例测定,检测RGH-0205 (Arg-Lys-Asp)、RGH-0206 (Arg-Lys-Asp- val)和TP-5 (Arg-Lys-Asp- val - try)寡肽的免疫刺激作用。虽然胸腺切除术延长了植皮和排斥之间的时间,但每一种寡肽都增加了脾脏T细胞的数量,并在一定程度上恢复了胸腺切除的C57Bl小鼠的排斥能力,可能是通过恢复胸腺激素功能。
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