Clinicopathological Features and Outcomes of T- and NK-Cell Lymphomas in European Russia

Y. Vinogradova, I. Kaplanskaya, R. S. Samoilova, I. Vorobiev, B. Zingerman, Y. Sidorova, N. Shklovskiy-Kordi, L. G. Aitova, D. C. Maryin, J. Morris, L. Varticovski, A. Vorobiev
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Abstract

With the introduction of the revised World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues in 2001, many patients had to be re-evaluated for the correct diagnosis of T- and NK-cell lymphomas. Because some T-cell malignancies are associated with poor outcome, it is important to identify subsets of patients that may benefit from novel or more intensive therapies. The purpose of this study was to determine, for the first time, the relative frequencies, pathological features and outcomes of patients with T- and NK-cell lymphomas in a predominantly Russian Slavic population. We identified 291 patients with a diagnosis of T- and NK-cell malignancies treated at our Center between 2000-2008. In applying the revised WHO classification, we confirmed the diagnosis and had complete clinical follow up and pathological information on 264 cases that were included in the analysis. We found some differences in frequency of several subsets as compared with previously published reports, including younger age of onset and relatively higher incidence of T-LGL in our patients. We also confirm that intensive treatment regimens of advanced stage PTCL and ALK—ALCL led to considerable improvement in response rates, but not in the overall survival.
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俄罗斯欧洲地区T细胞和nk细胞淋巴瘤的临床病理特征和预后
随着2001年世界卫生组织修订的《造血和淋巴组织肿瘤分类》的引入,许多患者必须重新评估才能正确诊断T细胞淋巴瘤和nk细胞淋巴瘤。由于一些t细胞恶性肿瘤与不良预后相关,因此确定可能从新的或更强化的治疗中受益的患者亚群是很重要的。本研究的目的是首次确定以俄罗斯斯拉夫人口为主的T细胞和nk细胞淋巴瘤患者的相对频率、病理特征和预后。在2000-2008年期间,我们确定了291例诊断为T细胞和nk细胞恶性肿瘤的患者。在应用修订后的WHO分类时,我们对纳入分析的264例病例进行了确诊和完整的临床随访和病理信息。与之前发表的报告相比,我们发现几个亚群的频率存在一些差异,包括发病年龄更年轻和患者中T-LGL的发病率相对较高。我们还证实,晚期PTCL和ALK-ALCL的强化治疗方案在缓解率方面有相当大的改善,但在总生存期方面没有改善。
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3.70
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审稿时长
8 weeks
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