Clinical Application Value of Combined Detection of CG and TBA in Differential Diagnosis of Hepatobiliary System Diseases

Natural Science Pub Date : 2022-01-01 DOI:10.4236/ns.2022.142008

Qiangcai Mai, Lihua Qan, Guosheng Su, Miaoling Liang, Xiaoye Su, Y. Gan, Qinglu Li, Cangrui Long, Huayan Zhu, Qiaocui Jiang, Yanling Zheng, Jie He, Tianwu Liang, Jing Li, Buqing Su

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Abstract

Objective: To understand the clinical value of combined detection of cholyglycine CG and TBA in differential diagnosis of hepatobiliary diseases. Methods: Serum samples from 50 healthy people were collected as healthy control group. According to the latest disease diagnosis and treatment plan, 58 cases of HBV asymptomatic carrier group, 17 cases of viral hepatitis group, 49 cases of cirrhosis group, 50 cases of primary liver cancer group and 50 cases of other hepatobiliary diseases groups were collected respectively. The concentration levels of cholyglycine and total bile acid in each group were detected, and the differences among each group were compared. Results: By statistical analysis, serum CG concentration in viral hepatitis group, cirrhosis group, primary liver cancer group and other hepatobiliary diseases group was significantly higher than that in asymptomatic HEPATITIS B carriers and healthy control group, the differences were statistically significant (p < 0.05). While, the serum CG concentration of asymptomatic hepatitis B virus carrier group was similar to that of healthy control group, the difference was not statistically significant (p > 0.05). There was

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CG与TBA联合检测在肝胆系统疾病鉴别诊断中的临床应用价值

目的:了解甘氨酸CG与TBA联合检测在肝胆疾病鉴别诊断中的临床价值。方法:采集50例健康人血清作为健康对照组。根据最新疾病诊疗方案，收集HBV无症状携带者组58例，病毒性肝炎组17例，肝硬化组49例，原发性肝癌组50例，其他肝胆疾病组50例。检测各组血清甘氨酸和总胆汁酸浓度水平，比较各组间差异。结果:经统计分析，病毒性肝炎组、肝硬化组、原发性肝癌组及其他肝胆疾病组患者血清CG浓度均显著高于无症状乙肝携带者及健康对照组，差异均有统计学意义(p < 0.05)。无症状乙肝病毒携带者组血清CG浓度与健康对照组相近，差异无统计学意义(p > 0.05)。有

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