ChemInform Abstract: On the Search for Potential anti-Trypanosoma cruzi Drugs: Synthesis and Biological Evaluation of 2-Hydroxy-3-methylamino and 1,2,3-Triazolic Naphthoquinoidal Compounds Obtained by Click Chemistry Reactions.

ChemInform Pub Date : 2012-08-30 DOI:10.1002/chin.201239148
Eufranio N. da Silva Junior, et al. et al.
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引用次数: 2

Abstract

2-Hydroxy-3-substituted aminomethyl napthoquinones, napthoquinone-based triazoles (III) and (VI), nor-β-lapachone-based triazoles (VIII) and further lapachol derivatives are prepared and evaluated against the infective bloodstream form of T.cruzi.

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摘要:寻找潜在的抗克氏锥虫药物:2-羟基-3-甲胺和1,2,3-三唑类萘醌类化合物的合成及生物学评价。
制备了2-羟基-3取代氨基甲基萘醌、萘醌基三唑(III)和(VI)、非β-拉帕康酮基三唑(VIII)和其他拉帕康衍生物,并对克氏锥虫的感染血流形式进行了评价。
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